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Overactive bladder
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Wet age related macular degeneration
Macular degeneration
Ocular inflammation
Ocular pain
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Systemic inflammatory response syndrome
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Inborn error of metabolism
Mucopolysaccharidosis
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Storage disease
Charcot Marie Tooth disease
Niemann Pick disease
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Cardiovascular development disorder
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Cocaine addiction
Diabetic foot ulcer
Esophagitis
Essential hypertension
Alcohol withdrawal syndrome
Alcoholism
Cough
Congenital lung disease
Bacterial infection
Bacterial respiratory tract infection
Mycobacterium tuberculosis infection
Aortic valve stenosis
Aortic stenosis
Steatohepatitis
Prescription drug abuse
Cells Expressing T Cell Surface Glycoprotein CD3 Epsilon Chain (T Cell Surface Antigen T3/Leu 4 Epsilon Chain or CD3E)
Isocitrate Dehydrogenase [NADP] Cytoplasmic (Oxalosuccinate Decarboxylase or Cytosolic NADP Isocitrate Dehydrogenase or IDP or NADP(+) Specific ICDH or IDH1 or EC 1.1.1.42)
Androgen Receptor (Dihydrotestosterone Receptor or Nuclear Receptor Subfamily 3 Group C Member 4 or DHTR or NR3C4 or AR)
Nuclear Factor Erythroid 2 Related Factor 2 (HEBP1 or Nuclear Factor Erythroid Derived 2 Like 2 or NFE2L2 or NRF2)
Tumor Necrosis Factor (Cachectin or TNF Alpha or Tumor Necrosis Factor Ligand Superfamily Member 2 or TNF a or TNF)
Cells Expressing ADP Ribosyl Cyclase/Cyclic ADP Ribose Hydrolase 1 (Cyclic ADP Ribose Hydrolase 1 or T10 or 2' Phospho ADP Ribosyl Cyclase/2' Phospho Cyclic ADP Ribose Transferase or ADP Ribosyl Cyclase 1 or CD38 or EC 3.2.2.6 or EC 2.4.99.20)
Innovator
Tyrosine Protein Kinase BTK (Bruton Tyrosine Kinase or B Cell Progenitor Kinase or Agammaglobulinemia Tyrosine Kinase or BTK or EC 2.7.10.2)
Tyrosine Protein Kinase ITK/TSK (Interleukin 2 Inducible T Cell Kinase or T Cell Specific Kinase or Kinase EMT or Tyrosine Protein Kinase Lyk or ITK or EC 2.7.10.2)
Tyrosine Protein Kinase JAK3 (Janus Kinase 3 or Leukocyte Janus Kinase or JAK3 or EC 2.7.10.2)
Receptor Type Tyrosine Protein Kinase FLT3 (FMS Like Tyrosine Kinase 3 or FL Cytokine Receptor or Stem Cell Tyrosine Kinase 1 or Fetal Liver Kinase 2 or CD135 or FLT3 or EC 2.7.10.1)
Cholinergic Receptor Muscarinic (Muscarinic Acetylcholine Receptor or CHRM)
Immunoglobulin E (IgE)
E Selectin (CD62 Antigen Like Family Member E or Endothelial Leukocyte Adhesion Molecule 1 or Leukocyte Endothelial Cell Adhesion Molecule 2 or LECAM2 or CD62E or SELE)
Geranylgeranyl Pyrophosphate Synthase (Geranylgeranyl Diphosphate Synthase or Dimethylallyltranstransferase or Farnesyl Diphosphate Synthase or Farnesyltranstransferase or Geranyltranstransferase or GGPS1 or EC 2.5.1.29 or EC 2.5.1.1 or EC 2.5.1.10)
CD3
Cells Expressing Leukocyte Antigen CD37 (Tetraspanin 26 or CD37)
Cells Expressing Tumor Necrosis Factor Receptor Superfamily Member 17 (B Cell Maturation Antigen or CD269 or BCMA or TNFRSF17)
Cells Expressing ADP Ribosyl Cyclase/Cyclic ADP Ribose Hydrolase 1 (Cyclic ADP Ribose Hydrolase 1 or T10 or 2' Phospho ADP Ribosyl Cyclase/2' Phospho Cyclic ADP Ribose Transferase or ADP Ribosyl Cyclase 1 or CD38 or EC 3.2.2.6 or EC 2.4.99.20)
Cannabinoid Receptor 1 (CB1 or CANN6 or CNR1)
Cannabinoid Receptor 2 (CB2 or CX5 or CNR2)
3-Oxo 5-Alpha Steroid 4 Dehydrogenase 2 (5 Alpha SR2 or Steroid 5 Alpha Reductase 2 or Type II 5 Alpha Reductase or SR Type 2 or SRD5A2 or EC 1.3.1.22)
Cells Expressing CD3
ATP Binding Cassette Sub Family G Member 2 (Breast Cancer Resistance Protein or Mitoxantrone Resistance Associated Protein or Placenta Specific ATP Binding Cassette Transporter or Urate Exporter or CD338 or ABCG2)
Substance P Receptor (Tachykinin Receptor 1 or NK 1 Receptor or NK1R or TACR1)
Granulocyte Colony Stimulating Factor Receptor (CD114 or GCSFR or CSF3R)
Cells Expressing Tumor Necrosis Factor Receptor Superfamily Member 13C (B Cell Activating Factor Receptor or BAFF Receptor or BLyS Receptor 3 or BAFFR or CD268 or TNFRSF13C)
Kappa Type Opioid Receptor (KOR1 or OPRK or OPRK1)
Mu Type Opioid Receptor (MOR1 or Mu Opiate Receptor or Mu Opioid Receptor or OPRM1)
Telomerase Reverse Transcriptase (HEST2 or Telomerase Catalytic Subunit or Telomerase Associated Protein 2 or TERT or EC 2.7.7.49)
Transient Receptor Potential Cation Channel Subfamily V Member 1 (Capsaicin Receptor or Vanilloid Receptor 1 or TRPV1)
Transforming Growth Factor Beta 2 (BSC1 Cell Growth Inhibitor or Cetermin or Glioblastoma Derived T Cell Suppressor Factor or Polyergin or TGFB2)
ORAI Calcium Release Activated Calcium Modulator (ORAI)
G Protein Coupled Bile Acid Receptor 1 (G Protein Coupled Receptor GPCR19 or Membrane Type Receptor For Bile Acids or hBG37 or GPR131 or GPBAR1)
Interleukin 12 Receptor (IL12R)
DNA Gyrase (EC 5.99.1.3)
DNA Topoisomerase IV (EC 5.99.1.3)
Interleukin 2 (T Cell Growth Factor or Aldesleukin or IL2)
Cells Expressing Cytotoxic T Lymphocyte Protein 4 (Cytotoxic T Lymphocyte Associated Antigen 4 or CD152 or CTLA4)
Granulocyte Macrophage Colony Stimulating Factor (GMCSF or Colony Stimulating Factor or CSF or Molgramostin or Sargramostim or CSF2)
Cells Expressing Melanoma Associated Antigen 6 (Cancer/Testis Antigen 1.6 or MAGE 6 Antigen or MAGE3B Antigen or MAGEA6)
Melanoma Antigen Recognized By T Cells 1 (Protein Melan A or Antigen SK29 AA or Antigen LB39 AA or MART1 or MLANA)
Tyrosinase (Monophenol Monooxygenase or Tumor Rejection Antigen AB or LB24 AB or SK29 AB or TYR or EC 1.14.18.1)
Erythropoietin Receptor (EPOR)
Beta 2 Microglobulin (B2M)
Microtubule Associated Protein Tau (Neurofibrillary Tangle Protein or Paired Helical Filament Tau or MAPT)
Forkhead Box Protein P3 (Scurfin or FOXP3)
GTPase HRas (GTP And GDP Binding Peptide B or Ha Ras1 Proto Oncoprotein or Harvey Rat Sarcoma Viral Oncoprotein or Transforming Protein p21 or HRAS or EC 3.6.5.2)
GTPase KRas (KRas 2 or Ki Ras or c K Ras or KRAS or EC 3.6.5.2)
GTPase NRas (Transforming Protein N Ras or NRAS or EC 3.6.5.2)
Amyloid Beta A4 Protein (ABPP or APPI or Alzheimer Disease Amyloid Protein or Amyloid Precursor Protein or Amyloid Beta Precursor Protein or Cerebral Vascular Amyloid Peptide or Prea4 or Protease Nexin II or APP)
Microtubule Associated Protein Tau (Neurofibrillary Tangle Protein or Paired Helical Filament Tau or MAPT)
E3 Ubiquitin Protein Ligase Pellino Homolog 1 (Pellino 1 or Pellino Related Intracellular Signaling Molecule or RING Type E3 Ubiquitin Transferase Pellino Homolog 1 or PELI1 or EC 2.3.2.27)
Glucagon Like Peptide 1 Receptor (GLP1R)
Farnesyl Pyrophosphate Synthase (Farnesyl Diphosphate Synthase or (2E,6E) Farnesyl Diphosphate Synthase or Dimethylallyltranstransferase or Geranyltranstransferase or FDPS or EC 2.5.1.10 or EC 2.5.1.1)
Interleukin 1 Receptor Associated Kinase 3 (IL 1 Receptor Associated Kinase M or IRAK3 or EC 2.7.11.1)
Parathyroid Hormone Receptor
Prostaglandin E2 Receptor EP4 Subtype (Prostanoid EP4 Receptor or PTGER4)
Solute Carrier Family 22 Member 12 (Organic Anion Transporter 4 Like Protein or Renal Specific Transporter or RST or Urate Anion Exchanger 1 or SLC22A12)
Acidic Mammalian Chitinase (Lung Specific Protein TSA1902 or CHIA or EC 3.2.1.14)
Chitotriosidase 1 (Chitinase 1 or CHIT1 or EC 3.2.1.14)
G Protein Coupled Receptor 183 (Epstein Barr Virus Induced G Protein Coupled Receptor 2 or EBI2 or GPR183)
Gamma-Aminobutyric Acid Type A Receptor Subunit (GABA(A) Receptor or GABR)
Receptor Tyrosine Protein Kinase ERBB 3 (Proto Oncogene Like Protein c ErbB 3 or Tyrosine Kinase Type Cell Surface Receptor HER3 or HER3 or ERBB3 or EC 2.7.10.1)
Tumor Necrosis Factor Ligand Superfamily Member 10 (Apo 2 Ligand or TNF Related Apoptosis Inducing Ligand or Protein TRAIL or CD253 or TNFSF10)
NADPH Oxidase (NOX or EC 1.6.3.1)
Integrin Alpha V (Vitronectin Receptor Subunit Alpha or CD51 or ITGAV)
Integrin Beta 3 (Platelet Membrane Glycoprotein IIIa or CD61 or ITGB3)
Macrophage Colony Stimulating Factor 1 Receptor (CSF 1 Receptor or Proto Oncogene c Fms or CD115 or CSF1R or EC 2.7.10.1)
Amyloid Beta A4 Protein (ABPP or APPI or Alzheimer Disease Amyloid Protein or Amyloid Precursor Protein or Amyloid Beta Precursor Protein or Cerebral Vascular Amyloid Peptide or Prea4 or Protease Nexin II or APP)
Diacylglycerol O Acyltransferase 1 (Diglyceride Acyltransferase 1 or ACAT Related Gene Product 1 or Acyl CoA Retinol O Fatty Acyltransferase or DGAT1 or EC 2.3.1.76 or EC 2.3.1.20)
Tyrosine Protein Kinase Receptor UFO (AXL Oncogene or AXL or EC 2.7.10.1)
Thrombospondin 1 (TSP1 or THBS1)
Somatostatin Receptor (SSTR)
Insulin Receptor (IR or CD220 or INSR or EC 2.7.10.1)
Cells Expressing B Lymphocyte Antigen CD19 (B Lymphocyte Surface Antigen B4 or Differentiation Antigen CD19 or T Cell Surface Antigen Leu 12 or CD19)
Cells Expressing B Lymphocyte Antigen CD20 (B Lymphocyte Surface Antigen B1 or Bp35 or Leukocyte Surface Antigen Leu 16 or Membrane Spanning 4 Domains Subfamily A Member 1 or CD20 or MS4A1)
Cells Expressing Receptor Tyrosine Protein Kinase ERBB 2 (Metastatic Lymph Node Gene 19 Protein or Proto Oncogene Neu or Proto Oncogene C ErbB 2 or Tyrosine Kinase Type Cell Surface Receptor HER2 or p185erbB2 or HER2 or CD340 or ERBB2 or EC 2.7.10.1)
Kelch Like ECH Associated Protein 1 (Cytosolic Inhibitor Of Nrf2 or Inrf2 or Kelch Like Protein 19 or KEAP1)
Transforming Growth Factor Beta (TGFb)
Glucagon Receptor (GL R or GCGR)
Transforming Growth Factor Beta 1 (TGFB1)
CD3
Cells Expressing Epithelial Cell Adhesion Molecule (Adenocarcinoma Associated Antigen or Cell Surface Glycoprotein Trop 1 or Epithelial Cell Surface Antigen or Epithelial Glycoprotein 314 or KS 1/4 Antigen or KSA or Tumor Associated Calcium Signal Transducer 1 or CD326 or EPCAM)
Dipeptidyl Peptidase 4 (ADABP or Adenosine Deaminase Complexing Protein 2 or T Cell Activation Antigen CD26 or TP103 or CD26 or DPP4 or EC 3.4.14.5)
Hydroxycarboxylic Acid Receptor 1 (G Protein Coupled Receptor 104 or G Protein Coupled Receptor 81 or GPR104 or GPR81 or HCAR1)
Calcium Channel
R Spondin 3 (Roof Plate Specific Spondin 3 or Protein With TSP Type 1 Repeat or Thrombospondin Type 1 Domain Containing Protein 2 or RSPO3)
Globohexaosylceramide (Globo H)
Vascular Endothelial Growth Factor Receptor 2 (Fetal Liver Kinase 1 or Kinase Insert Domain Receptor or Protein Tyrosine Kinase Receptor flk 1 or VEGFR2 or CD309 or KDR or EC 2.7.10.1)
Dihydroorotate Dehydrogenase (Quinone) Mitochondrial (Dihydroorotate Oxidase or DHODH or EC 1.3.5.2)
Tubulin
Fructose Bisphosphatase (Fructose 1,6 Bisphosphatase or FBPase or EC 3.1.3.11)
Thyroid Hormone Receptor Beta (Nuclear Receptor Subfamily 1 Group A Member 2 or c erbA 2 or c erbA Beta or ERBA2 or THRB)
Cyclin Dependent Kinase 4 (Cell Division Protein Kinase 4 or PSK J3 or CDK4 or EC 2.7.11.22)
Cyclin Dependent Kinase 6 (Cell Division Protein Kinase 6 or Serine/Threonine Protein Kinase PLSTIRE or CDK6 or EC 2.7.11.22)
Mothers Against Decapentaplegic Homolog 7 (MAD Homolog 7 or Mothers Against DPP Homolog 7 or Mothers Against Decapentaplegic Homolog 8 or SMAD7)
Cells Expressing GTPase KRas (KRas 2 or Ki Ras or c K Ras or KRAS or EC 3.6.5.2)
Heat Shock Protein 90 (HSP90)
Cyclin Dependent Kinase 1 (p34 Protein Kinase or Cell Division Protein Kinase 1 or Cell Division Control Protein 2 Homolog or CDK1 or EC 2.7.11.22 or EC 2.7.11.23)
78 kda Glucose Regulated Protein (Endoplasmic Reticulum Lumenal Ca(2+) Binding Protein Grp78 or Heat Shock 70 kDa Protein 5 or Immunoglobulin Heavy Chain Binding Protein or HSPA5)
Muscarinic Acetylcholine Receptor M3 (CHRM3)
Sialic Acid Binding Ig Like Lectin 15 (CD33 Antigen Like 3 or SIGLEC15)
Cells Expressing CD44 Antigen (CDw44 or Epican or Extracellular Matrix Receptor III or GP90 Lymphocyte Homing/Adhesion Receptor or HUTCH I or Heparan Sulfate Proteoglycan or Hermes Antigen or Hyaluronate Receptor or Phagocytic Glycoprotein 1 or CD44)
Alpha Enolase (2 Phospho D Glycerate Hydro Lyase or C myc Promoter Binding Protein or Enolase 1 or MBP1 or MPB1 or Non Neural Enolase or Plasminogen Binding Protein or ENO1 or EC 4.2.1.11)
Poly [ADP Ribose] Polymerase 1 (ADP Ribosyltransferase Diphtheria Toxin Like 1 or NAD(+) ADP Ribosyltransferase 1 or Poly[ADP Ribose] Synthase 1 or PARP1 or EC 2.4.2.30)
Poly [ADP Ribose] Polymerase 2 (ADP Ribosyltransferase Diphtheria Toxin Like 2 or NAD(+) ADP Ribosyltransferase 2 or Poly[ADP Ribose] Synthase 2 or PARP2 or EC 2.4.2.30)
Cells Expressing CD276 Antigen (B7 Homolog 3 or 4Ig B7 H3 or Costimulatory Molecule or CD276)
Hepatocyte Growth Factor (Hepatopoietin A or Scatter Factor or HGF)
Cells Expressing Epidermal Growth Factor Receptor (Proto Oncogene c ErbB 1 or Receptor Tyrosine Protein Kinase erbB 1 or HER1 or ERBB1 or EGFR or EC 2.7.10.1)
Peptidyl Prolyl Cis Trans Isomerase FKBP4 (51 Kda FK506 Binding Protein or 52 Kda FK506 Binding Protein or 59 Kda Immunophilin or FK506 Binding Protein 4 or HSP Binding Immunophilin or Immunophilin FKBP52 or Rotamase or p59 or FKBP59 or FKBP52 or FKBP51 or FKBP4 or EC 5.2.1.8)
Interleukin 4 Receptor Subunit Alpha (CD124 or IL4R)
Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A (Serine/Threonine Kinase MNB or MNB/DYRK Protein Kinase or Dual specificity YAK1 Related Kinase or HP86 or Protein Kinase Minibrain Homolog or DYRK1A or EC 2.7.12.1)
Arginase 1 (Liver Type Arginase or Type I Arginase or ARG1 or EC 3.5.3.1)
Arginase 2 Mitochondrial (Kidney Type Arginase or Type II Arginase or Non Hepatic Arginase or ARG2 or EC 3.5.3.1)
Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor or Heparin Binding Growth Factor 2 or FGF2)
ADP Ribosyl Cyclase/Cyclic ADP Ribose Hydrolase 1 (Cyclic ADP Ribose Hydrolase 1 or T10 or 2' Phospho ADP Ribosyl Cyclase/2' Phospho Cyclic ADP Ribose Transferase or ADP Ribosyl Cyclase 1 or CD38 or EC 3.2.2.6 or EC 2.4.99.20)
Gonadotropin Releasing Hormone Receptor (GNRHR)
Bifunctional Epoxide Hydrolase 2 (Cytosolic Epoxide Hydrolase 2 or Epoxide Hydratase or Soluble Epoxide Hydrolase or Lipid Phosphate Phosphatase or EPHX2 or EC 3.3.2.10 or EC 3.1.3.76)
Voltage Dependent T Type Calcium Channel
Histone Deacetylase 6 (Protein Phosphatase 1 Regulatory Subunit 90 or HDAC6 or EC 3.5.1.98)
Chloride Channel
Alpha Synuclein (Non A Beta Component Of AD Amyloid or Non A4 Component Of Amyloid Precursor or NACP or SNCA)
Patatin Like Phospholipase Domain Containing Protein 2 (Adipose Triglyceride Lipase or Calcium Independent Phospholipase A2 or Desnutrin or IPLA2 Zeta or PEDF-R or TTS2.2 or Transport Secretion Protein 2 or ATGL or PNPLA2 or EC 3.1.1.3)
Lactate Dehydrogenase (EC 1.1.1.)
Interferon Gamma (Immune Interferon or IFNG)
Tyrosine Protein Kinase SYK (Spleen Tyrosine Kinase or p72 Syk or SYK or EC 2.7.10.2)
Aminopeptidase N (Myeloid Plasma Membrane Glycoprotein CD13 or Alanyl Aminopeptidase or Aminopeptidase M or Microsomal Aminopeptidase or gp150 or CD13 or ANPEP or EC 3.4.11.2)
Neprilysin (Neutral Endopeptidase 24.11 or Atriopeptidase or Common Acute Lymphocytic Leukemia Antigen or Skin Fibroblast Elastase or Enkephalinase or CD10 or MME or EC 3.4.24.11)
Complement C5 (C3 And PZP Like Alpha 2 Macroglobulin Domain Containing Protein 4 or C5)
Toll Like Receptor 4 (hToll or CD284 or TLR4)
Toll Like Receptor Family (TLR)
Vascular Endothelial Growth Factor A (Vascular Permeability Factor or VEGFA)
Protein Arginine Deiminase Type 4 (HL 60 PAD or PADI H Protein or Peptidylarginine Deiminase IV or PADI4 or EC 3.5.3.15)
Interferon Alpha/Beta Receptor 1 (Cytokine Receptor Class II Member 1 or Cytokine Receptor Family 2 Member 1 or Type I Interferon Receptor 1 or IFNAR1)
Interferon Alpha/Beta Receptor 2 (Interferon Alpha Binding Protein or Type I Interferon Receptor 2 or IFNAR2)
Glucocorticoid Receptor (GR or Nuclear Receptor Subfamily 3 Group C Member 1 or NR3C1)
TGF Beta Receptor Type 1 (Activin A Receptor Type II Like Protein Kinase Of 53kD or Activin Receptor Like Kinase 5 or Serine/Threonine Protein Kinase Receptor R4 or Transforming Growth Factor Beta Receptor Type I or ALK5 or TGFBR1 or EC 2.7.11.30)
Huntingtin (Huntington Disease Protein or HTT)
Alpha Adrenergic Receptor (ADRA)
Beta Adrenergic Receptor (ADRB)
Calcineurin (Protein Serine/Threonine Phosphatase 3 or Protein Phosphatase 3 or EC 3.1.3.16)
Tissue Factor (Coagulation Factor III or Thromboplastin or CD142 or F3)
Atrial Natriuretic Peptide Receptor 1 (Atrial Natriuretic Peptide Receptor Type A or Guanylate Cyclase A or NPR1 or EC 4.6.1.2)
Complement Factor I (C3B/C4B Inactivator or CFI or EC 3.4.21.45)
Vascular Endothelial Growth Factor (VEGF)
Angiopoietin 1 Receptor (Endothelial Tyrosine Kinase or Tunica Interna Endothelial Cell Kinase or Tyrosine Kinase With Ig And EGF Homology Domains 2 or Tyrosine Protein Kinase Receptor TEK or Tyrosine Protein Kinase Receptor TIE 2 or p140 TEK or CD202b or TIE2 or TEK or EC 2.7.10.1)
Chymase (Alpha Chymase or Mast Cell Protease I or CMA1 or EC 3.4.21.39)
Interleukin 21 (Za11 or IL21)
Insulin Like Growth Factor 1 Receptor (CD221 or IGF1R or EC 2.7.10.1)
Insulin Like Growth Factor I (Mechano Growth Factor or Somatomedin C or IGF1)
Nuclear Factor Kappa B (NFKB)
Platelet Derived Growth Factor Subunit B (PDGF2 or Platelet Derived Growth Factor B Chain or Platelet Derived Growth Factor Beta Polypeptide or Proto Oncogene c Sis or Becaplermin or PDGFB)
Tumor Necrosis Factor Receptor Superfamily Member 1B (Tumor Necrosis Factor Receptor 2 or p75 or p80 TNF Alpha Receptor or CD120b or TNFRSF1B)
Vascular Endothelial Growth Factor Receptor 1 (Fms Like Tyrosine Kinase 1 or Tyrosine Protein Kinase Receptor FLT or Tyrosine Protein Kinase FRT or Vascular Permeability Factor Receptor or VEGFR1 or FLT1 or EC 2.7.10.1)
Vascular Endothelial Growth Factor Receptor 2 (Fetal Liver Kinase 1 or Kinase Insert Domain Receptor or Protein Tyrosine Kinase Receptor flk 1 or VEGFR2 or CD309 or KDR or EC 2.7.10.1)
Cadherin 5 (7B4 Antigen or Vascular Endothelial Cadherin or CD144 or CDH5)
Chitin Synthase (EC 2.4.1.16)
DPP4
Immunomodulator
Anticancer monoclonal antibody
Isocitrate dehydrogenase gene inhibitor
Anti acne product category
Topical anti-acne product
Antipsoriatic product category
Topical antipsoriatic product
Anti-inflammatory
Non-steroidal anti-inflammatory
Gene target
Other actions
Protein target
Ras interference interaction gene inhibitor
Kinase suppressor of Ras gene inhibitor
Anticancer
Neurokinin modulator
Granulocyte modulator
DNA damage reversal pathway modulator
Dermatological agent
TRPV1 gene modulator
Cell cycle inhibitor
Immunostimulant
Therapeutic vaccine
TGF beta receptor associated protein 1 modulator
Other dermatological product
EPO gene modulator
Tau protein modulator
Tau deposition inhibitor
Tau aggregation inhibitor
Cell organelle modulator
DNA replication regulation pathway modulator
G protein coupled receptor antagonist
Receptor modulator
Beta amyloid modulator
Autophagy protein gene modulator
Lipid metabolism modulator
Lysosomal-trafficking regulator modulator
Genetic modulator
Gene therapy
Antisense oligonucleotide inhibitor
Ras gene modulator
Tau protein inhibitor
Unspecified drug target
Protein ligand
Unspecified vaccine
Necroptosis inhibitor
Free radical scavenger
Calcium uptake protein modulator
Mitochondrial fission process protein modulator
Pathway modulator
CNS modulator
Nootropic agent
Unspecified receptor modulator
Unspecified receptor agonist
Unspecified receptor antagonist
Putative receptor modulator
Protein FAM modulator
Protein FAM19 modulator
Protein FAM inhibitor
Cell modulator
Signaling molecule modulator
Neuroprotectant
Mitotic cell cycle pathway modulator
Transforming growth factor ligand inhibitor
Enzyme modulator
Enzyme inhibitor
G protein coupled receptor modulator
Gastrointestinal system agent
Biochemical metabolism modulator
ACE inhibitor
Beta amyloid synthesis inhibitor
Beta amyloid antagonist
Amyloid protein deposition inhibitor
Musculoskeletal system modulator
DGAT gene inhibitor
Adjuvant
Antidepressant
AXL gene modulator
Angiogenesis inhibitor
CD47 antagonist
Thrombospondin ligand
DNA vaccine
Hormone modulator
Insulin-like growth factor modulator
Growth hormone ligand inhibitor
Human insulin long acting product
Insulin modulator
Immune recognition receptor modulator
T-cell CD3 glycoprotein zeta chain modulator
Cytostatic
NOX gene inhibitor
Defence protein inhibitor
Reactive oxygen species modulator inhibitor
Transforming Growth Factor Beta (TGFB) Inhibitor
Immunosuppressant
Anticancer antibody
Cell differentiation stimulator
Apoptosis inhibitor
RSPO3 inhibitor
Immunoglobulin M modulator
Immunoglobulin G modulator
VEGF modulator
Apoptosis pathway modulator
Thyroid hormone modulator
Toxoid vaccine
Adeno-associated virus based gene therapy
Protein synthesis modulator
TGF beta ligand modulator
GDF-8 modulator
Autophagy protein modulator
Cellular process pathway modulator
Defence protein modulator
Reactive oxygen species modulator modulator
Immune recognition receptor antagonist
Cell control agent
PARP gene inhibitor
DNA repair protein modulator
DNA repair protein inhibitor
Androgen modulator
Hepatocyte growth factor ligand
Immunotoxin
Interleukin ligand modulator
Mitosis S phase pathway modulator
Anticancer polyclonal antibody
Cell cycle checkpoint pathway modulator
Bone synthesis modulator
Steroid hormone modulator
Estrogen modulator
Physiological process pathway modulator
Regulatory protein modulator
Histone deacetylase complex modulator
Histone deacetylase complex inhibitor
Ion channel modulator
Stem cell stimulator
Stem cell factor modulator
LDHA gene modulator
Ophthalmological corticosteroid
Topical antiglaucoma agent
Interferon beta ligand modulator
Steroidal anti-inflammatory
siRNA agent
Ocular antineovascularisation agent
Cardiovascular agent
Respiratory system agent
Blood pressure modulator
Bronchodilator
Blood clotting modulator
Platelet aggregation inhibitor
Cell process modulator
Chemokine CXC ligand modulator
Angiogenesis stimulator
Tyrosine kinase receptor modulator
Serine-threonine kinase receptor modulator
Viral vector based gene therapy
Adenovirus based gene therapy
Antimicrobial
Antibacterial
Antiviral
Chemotaxis modulator
Analgesic
Opioid modulator
Pain modulator
Glutamate Ionotropic Receptor (GRI) Antagonist
Voltage Gated Sodium Channel (SCN) Blocker
Gamma-Aminobutyric Acid Type A Receptor Subunit (GABA(A) Receptor or GABR) Agonist
Fibrinolysis stimulator
Factor XI modulator
Lipid uptake modulator
Lipid transporter inhibitor
Lipid transporter modulator
Protein subunit vaccine
HDAC6 inhibitor
Non-viral vector based gene therapy （Cystic Fibrosis Transmembrane Conductance Regulator (ATP Binding Cassette Sub Family C Member 7 or Channel Conductance Controlling ATPase Camp Dependent Chloride Channel or ABCC7 or CFTR or EC 5.6.1.6) Activator）
Vascular leakage blocker by Solvadys™ Technology (Vasoprotectant) Enhanced survival rate of vascular endothelial cells and fundamentally blocked endothelial cell dysfunction through structural modification of actin.
Stabilizes EC junction and strongly block vascular leakage through cAMP/cortactin pathway
Angiogenesis modulator
Antipsychotic
VEGF-A ligand modulator
Vascular agent
undisclosed
Nuclear hormone receptor gene inhibitor
JAK gene modulator
Pemziviptadil (PDP-20418) acts as a vasoactive intestinal polypeptide receptor 2 (VPAC2) agonist. It enhances the activation of G-protein-coupled vasoactive intestinal peptide receptor 2,it activates adenylyl cyclase,potentially triggering the vasodilation of vessels leading to reduction in the blood pressure. The high selectivity for binding to the VPAC2 receptor reduces the potential complications of gastrointestinal side effects believed to be associated with interaction of VIP with the VPAC1 receptor.
PDP-20420 acts by reversing the antiplatelet effect of ticagrelor and AR-C124910XX,the ticagrelor active metabolite (TAM). The drug competes with ticagrelor and TAM for binding with the receptor. Basing on its high affinity towards the receptor,the binding reverses both the antiplatelet activity and the drug-induced bleeding. It also helps to prevent the formation of blood clots and reduces the occurrence of thrombotic events.
Nucleolin modulator
Glutamate Ionotropic Receptor NMDA Type Subunit (NMDAR or GRIN) Antagonist
Von Willebrand Factor (VWF) Inhibitor
G protein coupled receptor agonist
CD antigen modulator
Cytokine receptor antagonist
Energy metabolism modulator
ATP modulator
Superoxide dismutase modulator
Calcium Channel Blocker
Potassium Channel (KCN) Blocker
Type 1 Angiotensin II Receptor (AT1AR or AT1BR or Angiotensin II Type 1 Receptor or AGTR1) Antagonist
Kinase suppressor of Ras modulator
ENO1 Inhibitor
Mitosis inhibitor
Apoptosis modulator
Chemosensitizer
Purinoceptor antagonist
P2X purinoceptor modulator
Bacterial protein synthesis inhibitor
Aminoglycoside antibiotic
Haven't applied yet
Applied
Expired
N/A'
Target identification/validation
Lead discovery/optimization
Preclinical testing
IND/CTA Filed
Phase 2
Phase 3
Pre registration
Registered
NDA/BLA Filing
On market
Class 1
Class 2
Class 3
Class 4
Class 5
Inhalational
Intratumor
Intravenous
Oral
Subcutaneous
Topical
Intraarticular
Intracerebral
Intracoronary
Intradermal
Intraocular
Intraperitoneal
Intrathecal
Intravitreal
Nasal
Ophthalmic
Parenteral
Transdermal
Rectal
Intravesical
Global
US
EU(incl. Canada,Australia,New Zealand)
UK
JP
China,mainland
India
Israel
Korea
TaiWan
Others (e.g. ASEAN，Russia,South Africa,etc.)
License-out
Co-R&D
Financing/M&A
CRO-Lab
CRO-Clinical
CMO/CDMO
CSO
MAH Rights Transfer
Pharma/Bio-Industrial park
Global Regulatory Affairs and Dossier Support
Others
Unknown
worldwide
America
Europe (incl. Canada, Australia, New Zealand)
U.K
Japan
China Mainland
India
Israel
South Korea
Taiwan area
Others (such as: ASEAN, Russia, South Africa, etc.)
